Prevent neurodegenerative diseases! Drink coffee like this to stay away from dementia and Parkinson’s disease

【Good Morning Health / Zhang Jinjian, Dr. Cai Chonghuang】
Coffee and neurological diseases

The general public thinks that drinking 200 mg of caffeine (about 2.5 cups of coffee) in one breath, or drinking no more than 400 mg of caffeine (5 cups) a day, is not harmful to the body, and has no effect on the alertness of the brain and nervous system. Health, concentration can help, and can reduce the risk of depression, as well as strengthening the effect of medication on headaches.

Long-term use of coffee or caffeine may prevent cognitive decline and reduce the risk of stroke, Parkinson’s disease, and Alzheimer’s disease, but may increase anxiety and disrupt sleep in some people.

In terms of epilepsy, the role of coffee is still controversial. In animal model studies, it was found that short-term use of caffeine will reduce the threshold of epilepsy and make seizures easier. On the contrary, in human studies, long-term use of coffee/caffeine has been found to reduce the risk of seizures. Reduces seizures and reduces brain damage in status epilepticus.

Kahweol protects nerve cells from damage, such as the neurotoxin 6-hydroxydopamine (6-OHDA), a neurotoxin that causes Parkinson's disease. Studies have found that cafestol can induce heme oxygenase-1 (heme oxygenase-1) via phosphatidylinositol 3-kinase (PI3K) and p38/Nrf2 pathways, and is derived from 6-hydroxyl 6-hydroxydopamine-derived oxidative stress to protect dopamine neurons.

Coffee reduces relative risk of Parkinson's disease through multiple mechanisms

Parkinson's disease (Parkinson's disease) is a neurodegenerative disease with an incidence second only to Alzheimer's disease. The cause is still unknown, but it is related to the degeneration of brain cells in the substantia nigra, which cannot produce enough dopamine (dopamine).

Why do substantia nigra cells degenerate? It is still unclear, and it is speculated that it may be related to genetic, environmental or life factors, such as the abuse of antibiotics, heavy metal pollution, etc. Several recent studies have shown that drinking coffee can actually prevent Parkinson's disease.

60 to 80% of people with Parkinson's disease have constipation problems that begin 10 to 20 years before symptoms appear. In 2014, a team from the Department of Neurology, National Taiwan University Hospital analyzed 550,000 Parkinson's disease cases in the health insurance database, and it was once again confirmed that people with constipation problems have a much higher chance of developing Parkinson's disease in the future than the general population, and the more severe the constipation, , the higher the probability.

((How many cups of coffee should I drink to reduce the risk of dementia? The answer is on the next page))

Study: Coffee helps prevent Alzheimer’s, Parkinson’s! Which is better: dark roast or light roast?

Coffee helps prevent Alzheimer's

A new study recently found that a cup of coffee in the morning not only lifts the spirits, but also protects against Alzheimer’s and Parkinson’s disease. Researchers at the Dolan-Doklopil Brain Institute found that phenylindanes, a chemical breakdown product of chlorogenic acid lactones in roasted coffee, inhibits the growth of Tau proteins and beta amyloid plaques, two proteins associated with increased risk of two diseases in the brain.

Regular Caffeine Intake May Help Prevent Dementia

According to Alzheimer’s and Dementia Weekly, Dr. Donald Weaver, co-director of the Crumbill Brain Institute, noted that coffee consumption appears to be associated with a reduced risk of Alzheimer’s and Parkinson’s disease, and they want to investigate what the cause is, what compounds are involved, and how it affects age-related cognitive decline.

Other studies have found that regular caffeine intake may help prevent dementia, AARP said. A study published in the Journal of Alzheimer’s Disease, which looked at people aged 65 to 84, showed that people who drank one to two cups of coffee a day were less likely to have mild cognitive impairment than those who never drank coffee. The American Association of Retired Persons pointed out that similar studies have found that coffee can even prevent Parkinson’s disease.

Dark-roasted coffee is more protective than light-roasted coffee

However, Canadian researchers have ruled out caffeine as a source of brain protection because even decaffeinated roasted coffee is beneficial in preventing dementia. The team determined that phenyl lindane, obtained through roasted coffee, is a beneficial compound that inhibits the aggregation of Tau and beta amyloid proteins in the brain associated with Alzheimer’s and Parkinson’s diseases.

The researchers also found that dark-roasted coffee, which contains more phenyl lindane, was more protective than light-roasted coffee, and the next step in the study is to measure how these compounds get into the bloodstream and cross the blood-brain barrier, and the good news is that phenyl lindane is a natural compound that has medicinal advantages over synthetic products. Dr. Weaver said that before coffee can be used to treat Alzheimer’s or Parkinson’s, more research is needed.

Prevent neurodegenerative diseases! Drink coffee like this to stay away from dementia and Parkinson’s disease